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Target intelligence / Profile preview
Complement C1s Protein (C1s)
- Target
- C1s
- Molecular classification
- Serine protease, Complement component
01
Overview
Complement C1s is a serine protease and a key component of the classical pathway of the complement system. Upon activation, it cleaves complement components C4 and C2, leading to downstream immune responses. Dysregulation or deficiency can lead to increased susceptibility to infections or autoimmune diseases. Elevated levels/activity have been associated with certain pathologies, making it a potential therapeutic target.
- Other names
- Complement Component 1SComplement esterase subcomponentComplement esterase A
02
Mechanism of action
Serine protease inhibitor (potential)
03
Biological functions
Classical pathway initiationCleavage of complement components C4 and C2Immune complex clearanceApoptotic cell removalInflammatory responseCleavage of cellular proteins affecting immunity/tissue homeostasis
04
Disease associations
Autoimmune diseasesInfections
05
Safety considerations
Dysregulation can lead to increased susceptibility to infections or autoimmune diseasesAberrant complement activation
06
Biomarkers
Elevated C1s levels/activity in certain pathologies
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