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Complement C1s subcomponent
- Molecular classification
- Enzyme, Serine Protease
01
Overview
Complement C1s subcomponent is a serine protease that forms part of the C1 complex, which initiates the classical pathway of the complement system. Activated C1s cleaves complement proteins C4 and C2, leading to further propagation of the complement cascade. Deficiency or dysfunction can result in immunodeficiency syndromes such as systemic lupus erythematosus or hereditary angioedema, while overactivity may contribute to autoimmune pathologies.
02
Mechanism of action
Serine endopeptidase; cleaves complement components C4 and C2
03
Biological functions
Innate immunity initiationOpsonizationCell lysisComplement activationClassical pathway activation
04
Disease associations
Systemic lupus erythematosusHereditary angioedemaAutoimmune diseasesImmunodeficiency
05
Safety considerations
Uncontrolled complement activationExcessive tissue damageInappropriate inflammatory responsesImmunodeficiency
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