Complement C3 mRNA (C3 mRNA)

Complement C3 mRNA is the transcript produced from the gene encoding complement component 3, a pivotal soluble glycoprotein of the complement cascade. The mRNA itself is not directly involved in immune functions but serves as the intermediary for protein production. The C3 protein plays a central role in innate immunity by opsonizing pathogens, stimulating inflammatory responses, and linking innate and adaptive immunity. Therapies target the protein rather than the mRNA; abnormal C3 levels or function are associated with a variety of immune and inflammatory diseases. Therefore, while 'Complement C3 mRNA' describes the genetic blueprint, it is the 'Complement component 3 (C3)' protein that is the relevant therapeutic target.

Other names

Complement C3 mRNAC3 transcriptC3Complement C3Complement component 3CO3

Inhibition of C3 activation, blockade of C3 convertase-mediated cleavage, prevention of downstream complement activation (reducing inflammation, tissue injury)