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Complement component 1 q subcomponent (C1q)
- Target
- C1q
- Molecular classification
- Protein Complex, Complement component
01
Overview
Complement component 1q (C1q) is a crucial protein complex in the classical pathway of the complement system, part of innate immunity. C1q, along with C1r and C1s, forms the C1 complex. This complex recognizes and binds to antigen-antibody complexes, leading to activation of the classical complement cascade. C1q deficiency is strongly associated with autoimmune diseases like SLE due to impaired clearance of apoptotic cells and immune complexes. It consists of three polypeptide chains A (C1QA), B (C1QB), and C (C1QC).
- Other names
- C1q complex
02
Mechanism of action
N/A
03
Biological functions
Innate immunityActivation of classical complement pathwayClearance of pathogensClearance of apoptotic cellsClearance of immune complexes
04
Disease associations
AutoimmunitySystemic lupus erythematosus (SLE)
05
Safety considerations
Potential for off-target effects on other complement pathwaysRisk of inducing or exacerbating autoimmune diseases if improperly targeted
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