Target intelligence / Profile preview

Complement Component 1 Subcomponent r (C1r)

Target: C1r
Molecular classification: Enzyme, Serine protease

Overview

Complement component 1 subcomponent r (C1r) is a serine protease enzyme that plays a critical role in the classical pathway of the complement system, which is part of the innate immune response. It combines with C1q and C1s to form the C1 complex, initiating the classical pathway of complement activation through cleavage of downstream components C4 and C2. Mutations in C1R are associated with Ehlers-Danlos syndrome periodontal type.

Other names: C1Rcomplement C1rEDSPD1

Mechanism of action

Serine protease activating complement cascade

Biological functions

Complement activation via classical pathwayImmune response

Disease associations

Ehlers-Danlos syndrome periodontal typeImmune disorders

Beyond the preview

Go deeper on Complement Component 1 Subcomponent r (C1r).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Complement Component 1 Subcomponent r (C1r).

Explore the full profile