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Complement component 1 subcomponent s
- Molecular classification
- Serine protease, Enzyme
01
Overview
Complement component 1 subcomponent s (C1s) is a serine protease and a key enzymatic component of the C1 complex, which initiates the classical pathway of the complement system in innate immunity. Once activated, C1s cleaves complement components C4 and then C2, leading to the formation of the classical pathway convertase (C4b2a). Dysregulation or deficiency can contribute to autoimmune diseases such as systemic lupus erythematosus (SLE), infections, or inflammatory conditions.
- Other names
- Complement component ¹ subcomponent sComplement esteraseActivated complement c¹ sEDSPD2
02
Mechanism of action
Cleaves complement components C4 and C2, activating the classical complement pathway
03
Biological functions
Innate immunityHost defenseComplement activationCleavage of complement components C4 and C2
04
Disease associations
Autoimmune diseasesSystemic lupus erythematosus (SLE)InfectionsInflammatory conditions
05
Safety considerations
Dysregulation or genetic deficiency can lead to increased susceptibility to infection or autoimmune diseases
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