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Complement Component 1s (C1s)
- Target
- C1s
- Molecular classification
- Serine protease, Enzyme
01
Overview
Complement component 1s (C1s) is a serine protease and a key enzymatic subunit of the C1 complex, which initiates the classical pathway of the complement system. Activated C1s specifically cleaves complement components C4 and C2, leading to the formation of the classical pathway convertase. Deficiency or dysfunction can result in immunodeficiencies or contribute to autoimmune diseases.
- Other names
- Complement esteraseActivated complement component c̄¹ sEDSPD2
02
Mechanism of action
C1s is a serine protease that cleaves complement components C4 and C2, initiating the classical pathway of complement activation.
03
Biological functions
Classical complement pathway activationComplement activationOpsonizationCell lysisImmune complex clearanceApoptotic cell clearance
04
Disease associations
ImmunodeficiencyAutoimmune diseasesSystemic Lupus ErythematosusHereditary Angioedema
05
Safety considerations
Dysfunctional C1s can lead to immunodeficiency or autoimmune disorders.Inhibition of C1s could disrupt the balance of the complement system, potentially leading to increased susceptibility to infection or impaired immune complex clearance.
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