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Complement component 1s subcomponent (None)

Target: None
Molecular classification: Serine protease, Enzyme

Overview

Complement component 1s (C1s) is a serine protease and a key enzyme in the classical pathway of the complement system. It forms part of the C1 complex, together with C1q and two molecules of C1r. Activated C1s cleaves complement components C4 and C2, which are critical for downstream events in the complement cascade including opsonization and cell lysis. Deficiency or dysfunction can result in immunodeficiency syndromes or contribute to autoimmune diseases.

Other names: CI esteraseactivated complement CI-s

Mechanism of action

Serine protease; cleaves C4 and C2

Biological functions

Complement activationImmune responseOpsonizationCell lysis

Disease associations

ImmunodeficiencyAutoimmune diseasesSystemic lupus erythematosusHereditary angioedema

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