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Complement Component 3 (C3)
- Target
- C3
- Molecular classification
- Complement protein, Alpha2-macroglobulin family
01
Overview
Complement component 3 (C3) is a central protein in the complement system, which is a crucial part of the innate immune response. C3 is primarily found in blood plasma and on cell surfaces, where it plays an essential role in defending against pathogens and coordinating immune responses. Upon activation by C3 convertase enzymes, C3 is cleaved into C3a and C3b, mediating inflammation and opsonization, respectively. Measurement of serum/plasma C3 levels helps diagnose/monitor autoimmune diseases, infections, and other conditions. Elevated expression is seen in some cancers.
- Other names
- C'3Complement C3
02
Mechanism of action
Pharmacologic targeting of C3 signaling
03
Biological functions
OpsonizationInflammationComplement activationImmune responsePathogen defense
04
Disease associations
Autoimmune diseasesSystemic lupus erythematosus (SLE)GlomerulonephritisSeptic shockEnd-stage liver diseaseInfections (fungal/parasitic/bacterial)Paroxysmal nocturnal hemoglobinuria (PNH)Cancer
05
Safety considerations
Excessive complement activationIncreased risk of bacterial infections (in case of deficiency)
06
Biomarkers
Serum C3 levels
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