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Complement component 3 convertase
- Molecular classification
- Enzyme, Serine protease complex
01
Overview
Complement component 3 convertase is a central enzyme complex in the complement system, a crucial part of innate immunity. It functions as a serine protease that cleaves complement component C3 into C3a and C3b, leading to opsonization, inflammation, and further activation of the complement cascade. It can be formed via the classical, lectin, and alternative pathways. Regulation is critical to prevent excessive activation and damage to host tissues.
- Other names
- C3 convertaseC4b2a (Classical/Lectin)C3bBb (Alternative)
02
Mechanism of action
Blocking assembly/activity/stability of C3 convertase
03
Biological functions
Immune responseOpsonizationInflammationComplement activationProteolysis
04
Disease associations
Autoimmune diseasesInflammatory diseasesKidney disordersInfection
05
Safety considerations
Potential for immunosuppressionOff-target effects on other complement componentsIncreased susceptibility to infection
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