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Complement Component 3 Fragment b
- Molecular classification
- Protein fragment, Complement protein, Opsonin
01
Overview
C3b is a crucial protein fragment in the complement system, generated by the proteolytic cleavage of complement component 3 (C3). It acts as an opsonin, tagging pathogens for phagocytosis and amplifying the complement response through convertase formation. C3b plays a key role in bridging innate and adaptive immunity and its deficiency leads to increased susceptibility to infections. Overactivation can contribute to inflammatory diseases.
02
Mechanism of action
Covalent surface attachment via exposed thioester bond
03
Biological functions
OpsonizationComplement activationImmune responsePhagocytosisConvertase formationBridging innate and adaptive immunity
04
Disease associations
InfectionInflammatory diseases
05
Safety considerations
Overactivation can contribute to inflammatory diseases
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