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Target intelligence / Profile preview
Complement component 3a receptor 1 (C3AR1)
- Target
- C3AR1
- Molecular classification
- G protein-coupled receptor (GPCR)
01
Overview
C3AR1 is a G protein-coupled receptor that binds the complement component C3a. It is expressed on various immune cells and tissues, mediating pro-inflammatory and immunomodulatory functions. It plays a role in diseases such as arthritis, obesity, cancer, and kidney disease. Both agonists and antagonists have been developed, making it a promising therapeutic target.
- Other names
- C3a receptorC3aR
02
Mechanism of action
Agonists activate intracellular signaling pathways (Gαi, Gα12/13, ERK1/2, Ca²⁺ increase). Antagonists block C3a binding and downstream signaling.
03
Biological functions
Immune responseInflammationSignal transductionTissue developmentTissue regenerationCell migrationStem cell homing
04
Disease associations
Autoimmune/inflammatory diseases (e.g., arthritis)Obesity/metabolic syndromeCancerKidney disease
05
Safety considerations
Dual roles in some diseases (e.g., kidney disease) necessitate careful consideration of pro-inflammatory vs. anti-inflammatory effects.Potential for off-target effects due to structural similarity to other GPCRs.
06
Interacting drugs
Small-molecule agonists
1 more in the full profile.
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