Target intelligence / Profile preview

Complement component 5a des-Arg (C5a des-Arg)

Target: C5a des-Arg
Molecular classification: Anaphylatoxin, Complement protein fragment

Overview

Complement component 5a des-Arg (C5a des-Arg) is a biologically active peptide derived from complement component C5a. It acts as a less potent anaphylatoxin and chemoattractant compared to C5a, playing a role in inflammation and immune responses by interacting with C5AR1 and C5L2 receptors. It is generated through enzymatic removal of a terminal arginine residue from C5a.

Mechanism of action

C5a des-Arg interacts with C5AR1 (CD88) and C5L2 (GPR77) receptors to mediate its effects.

Biological functions

InflammationImmune responseChemotaxisMast cell activation

Disease associations

Autoimmune diseasesInflammatory diseases

Safety considerations

Potential to exacerbate inflammatory responses if not properly regulated.

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