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Target intelligence / Profile preview
Complement Component 5a Receptor 1 (C5aR1)
- Target
- C5aR1
- Molecular classification
- G protein-coupled receptor, GPCR, Rhodopsin-like GPCR superfamily, Receptor
01
Overview
Complement Component 5a Receptor 1 (C5aR1), also known as CD88, is a G protein-coupled receptor (GPCR) that binds the complement component C5a. It is expressed on various immune cells and mediates inflammatory responses by promoting chemotaxis, cytokine secretion, and other immune functions. Dysregulation of C5aR1 contributes to several diseases, making it a therapeutic target for autoimmune diseases, sepsis, and cancer.
- Other names
- C5aRCD88Complement component 5a receptor
02
Mechanism of action
Agonists and antagonists modulate inflammatory responses through binding to C5aR1, affecting downstream signaling pathways like Gαi coupling, β-arrestin recruitment, and ERK/CAMK/Rho activation.
03
Biological functions
Signal transductionImmune responseChemotaxisCytokine secretionPhagocytosisDegranulationOxidative burstInflammation
04
Disease associations
Autoimmune diseasesSepsisCancerObesity-related inflammationNeuroinflammation
05
Safety considerations
Potential for broad immunosuppression with antagonistsRisk of exacerbating infections if immune cell recruitment is blocked excessively
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