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Target intelligence / Profile preview
Complement Component 5a Receptor 2 (C5aR2)
- Target
- C5aR2
- Molecular classification
- Anaphylatoxin receptor, G protein-coupled receptor (GPCR) superfamily
01
Overview
Complement component 5A receptor 2 (C5AR2/C5L2/GPR77) is an atypical member of the anaphylatoxin receptor family involved in fine-tuning inflammatory processes through complex regulatory mechanisms beyond simple ligand sequestration. It represents both a challenge and opportunity for immunology research due to its nuanced roles across health and disease states.
- Other names
- C5L2GPR77
02
Mechanism of action
Modulation of C5a-mediated signaling, β-arrestin recruitment, ERK signaling modulation, regulation of NLRP3 inflammasome activity.
03
Biological functions
Regulation of inflammationModulation of innate immune responsesTransendothelial migration of neutrophilsERK signaling pathway modulationLipid metabolism regulationImmune response
04
Disease associations
SepsisLung injuryHemorrhagic shockObesity-related inflammationEpidermolysis bullosa acquisitaInflammatory diseasesAutoimmune diseases
05
Safety considerations
Complex and context-dependent role in inflammation (potential for both pro- and anti-inflammatory effects)Lack of highly selective ligands for pharmacological targeting
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