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Complement Component 9 (C9)

Target: C9
Molecular classification: Protein, Membrane Attack Complex/Perforin superfamily

Overview

Complement component 9 (C9) is a terminal protein of the complement system, crucial for the innate immune response. It polymerizes to form transmembrane pores in target cells as part of the membrane attack complex (MAC), leading to cell lysis and death. C9 deficiency increases susceptibility to Neisseria meningitidis infections.

Other names: ARMD15C9Dcomplement component 9complement C9

Biological functions

Immune responseCell lysisPore formation

Disease associations

InfectionImmunodeficiency

Safety considerations

Increased susceptibility to Neisseria meningitidis infections in deficient individualsPotential for off-target effects if targeted therapeutically, given its role in immune defense

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