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Target intelligence / Profile preview
Complement component C3 convertase (C3 convertase)
- Target
- C3 convertase
- Molecular classification
- Enzyme, Serine protease, Heterodimeric complex, Enzyme complex
01
Overview
Complement component C3 convertase is a central enzyme complex in the complement system. It catalyzes the cleavage of complement protein C3 into C3a and C3b, leading to opsonization, inflammation, and further activation of the complement cascade. There are two main forms: C4b2a (classical/lectin pathway) and C3bBb (alternative pathway). Its activity is tightly regulated to prevent excessive complement activation.
- Other names
- C3-convertaseC3 convertase
02
Mechanism of action
Inhibition of C3 convertase activity, Stabilization of C3 convertase, Promoting dissociation/inactivation of C3 convertase
03
Biological functions
Complement activationOpsonizationInflammationImmune response amplificationProteolytic cleavage of C3
04
Disease associations
Infection susceptibilityAutoimmune diseasesInflammatory diseasesTissue damage
05
Safety considerations
Increased susceptibility to infectionsExcessive tissue damage
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