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Complement Component C3d (C3d)
- Target
- C3d
- Molecular classification
- Complement protein fragment
01
Overview
Complement component C3d is a proteolytic fragment of complement component 3 (C3). It enhances B cell responses by binding to CR2/CD21, bridging innate and adaptive immunity. While primarily known as a B cell co-stimulator, it also contains T-cell epitopes capable of stimulating helper T-cells, potentially contributing to autoimmunity under certain conditions.
02
Mechanism of action
Acts as a molecular adjuvant by binding to CR2/CD21 on B cells, enhancing B cell receptor signaling and lowering the threshold for activation. May also stimulate autoreactive T cells independently of CR2 engagement.
03
Biological functions
Immune responseB cell activation enhancementOpsonizationAdaptive immunity bridge
04
Disease associations
Autoimmune diseaseInfection
05
Safety considerations
Potential for stimulating autoreactive T-cell responses
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