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Complement Component C5 Convertase (C5 convertase)
- Target
- C5 convertase
- Molecular classification
- Enzyme, Serine protease, Multi-subunit enzyme complex
01
Overview
Complement component C5 convertase is a crucial enzyme complex in the complement system that cleaves C5 into C5a and C5b. This cleavage is a critical step in innate immunity, leading to inflammation via C5a and the formation of the membrane attack complex (MAC) via C5b, resulting in pathogen lysis. The enzyme exists in different forms depending on the activation pathway (classical, alternative, or lectin) and its activity is tightly regulated to prevent excessive inflammation.
- Other names
- C4b2a3bC4b2b3bC3bBbC3bC4b2aoxy3bC4b2boxy3bCVFBbClassical Pathway C5 ConvertaseAlternative Pathway C5 ConvertaseFluid Phase Classical Pathway C5 ConvertaseCobra Venom Factor-Dependent C5 Convertase
02
Mechanism of action
Cleaves complement protein C5 into C5a and C5b, initiating downstream immune responses.
03
Biological functions
Complement activationInnate immunityInflammationPathogen lysisChemotaxisAnaphylaxis
04
Disease associations
InfectionInflammationAutoimmune diseasesSepsis
05
Safety considerations
Uncontrolled complement activation leading to inflammation and tissue damageIncreased susceptibility to infection if excessively inhibited
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