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Complement Component C5b-9 (MAC)
- Target
- MAC
- Molecular classification
- Multi-protein complex, Complement System Component
01
Overview
Complement component C5b-9, also known as the membrane attack complex (MAC) or terminal complement complex (TCC), is a multi-protein structure formed during activation of the complement system. The MAC is assembled from complement proteins C5b, C6, C7, C8, and multiple copies of C9. Its primary function is to form transmembrane pores in target cell membranes, leading to cell lysis and death. It must be tightly regulated to avoid damage to host tissues. Dysregulation or deficiency can result in disease. Therapeutic targeting is possible.
- Other names
- Membrane Attack ComplexTerminal Complement ComplexTCCC5b-9
02
Mechanism of action
Inhibition of C5 cleavage
03
Biological functions
Pore formationCell lysisImmune responseCell signaling
04
Disease associations
InfectionAutoimmune diseasesMultiple sclerosisInflammation
05
Safety considerations
Increased susceptibility to infection (with upstream inhibition)Off-target effects on host cells
06
Interacting drugs
Eculizumab
07
Biomarkers
Circulating levels of C5b-9
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