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Target intelligence / Profile preview
Complement Components C5b-9 Membrane Attack Complex (MAC)
- Target
- MAC
- Molecular classification
- Multi-protein complex
01
Overview
The complement membrane attack complex (MAC), also known as the C5b-9 complex, is a multi-protein structure formed during the terminal phase of complement activation. It is a critical effector mechanism of innate immunity, responsible for directly lysing target cells such as bacteria by forming transmembrane pores that disrupt cellular integrity. Dysregulation or excessive formation can contribute to tissue injury in autoimmune diseases.
- Other names
- Membrane Attack ComplexTerminal Complement ComplexC5b-9 complex
02
Mechanism of action
Pore formation leading to osmotic lysis
03
Biological functions
CytolysisPore formationImmune responseCell death
04
Disease associations
Autoimmune diseasesInflammationInfection
05
Safety considerations
Excessive formation can contribute to tissue injury
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