Complement factor H-related protein 5 (CFHR5)

Complement factor H-related protein 5 is a 65 kDa plasma glycoprotein composed of nine short consensus repeat (SCR) domains, encoded by the CFHR5 gene on chromosome 1q31.3. It shares structural similarity with complement factor H and acts as a regulator of the complement system, having both inhibitory and activating functions depending on physiological conditions and local context. CFHR5 binds to complement fragments (notably C3b), heparin, C-reactive protein, and interacts with properdin, forming oligomeric complexes that modulate complement activation especially at sites of tissue damage such as the glomerular endothelium. Mutations or copy number variations in CFHR5 are causally associated with C3 glomerulopathy and are especially prevalent in specific populations, such as those in Cyprus. The exact physiological and pathophysiological roles of CFHR5 continue to be investigated, especially with regard to its interaction with complement cascade components and its potential involvement in kidney disease and other immune-mediated conditions.

Other names

CFHR5FHR5FHR-5CFHL5factor H related protein 5CFHR5Dcomplement factor H-related protein 5factor H-related protein 5

Drugs targeting CFHR5 (theoretical) would aim to modulate its regulatory action on the complement cascade to prevent excessive activation and subsequent tissue damage