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Target intelligence / Profile preview
Complement membrane attack complex C5b-9 (MAC)
- Target
- MAC
- Molecular classification
- Protein complex, Pore-forming complex
01
Overview
The complement membrane attack complex (MAC), also known as C5b-9, is a multi-protein complex formed on the surface of target cells. It is composed of complement proteins C5b, C6, C7, C8, and multiple copies of C9. Upon assembly, it forms a transmembrane pore, disrupting the cell membrane and leading to cell lysis. While essential for innate immunity against pathogens, its dysregulation can contribute to tissue injury in various diseases.
- Other names
- Membrane attack complexTerminal complement complexTCCscC5b-9
02
Mechanism of action
Pore formation leading to cell lysis
03
Biological functions
Cell lysisImmune defensePore formationMembrane permeabilization
04
Disease associations
InfectionAutoimmune disordersCancerInflammation
05
Safety considerations
Inappropriate activation leading to host cell damagePotential for off-target effects
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