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Complement Pathway Proteins (Complement Proteins)
- Target
- Complement Proteins
- Molecular classification
- Enzyme, Serine protease, Opsonin, Anaphylatoxin, Receptor, Other
01
Overview
Complement pathway proteins are a group of more than 30 soluble and membrane-bound plasma proteins that play a central role in innate immunity. They function as part of the complement system, which is one of the body's primary mechanisms for recognizing and eliminating pathogens. Activation leads to opsonization, chemotaxis & inflammation, and direct lysis. Dysregulation is associated with infections and autoimmune diseases.
- Other names
- Complement System ProteinsComplement Components
02
Mechanism of action
Varies depending on the specific protein and inhibitor; generally involves blocking proteolytic cleavage, receptor binding, or complex formation within the complement cascade.
03
Biological functions
Immune responseOpsonizationChemotaxisInflammationCell lysisClearance of immune complexesB-cell activation
04
Disease associations
Infection susceptibilityAutoimmune diseasesHereditary angioedemaInflammation
05
Safety considerations
Increased risk of infection with complement inhibitionInfusion reactions with protein-based inhibitorsThrombotic microangiopathy (TMA) with some complement inhibitorsPotential for off-target effects due to the complexity of the complement system
06
Interacting drugs
C1-inhibitor
2 more in the full profile.
07
Biomarkers
C3 levelsC4 levelsFactor B levelsComplement activity assays (e.g., CH50, AP50)
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