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Target intelligence / Profile preview
Complement Protein C5b-C9 Membrane Attack Complex (MAC)
- Target
- MAC
- Molecular classification
- Multi-protein complex, Pore-forming complex, Complement system component
01
Overview
The complement protein C5b-C9 membrane attack complex (MAC) is a multi-protein structure formed during activation of the complement system. The MAC forms transmembrane pores in target cell membranes, leading to cell lysis and death. It is composed of C5b, C6, C7, C8, and multiple copies of C9. Excessive or misdirected activation contributes to tissue damage in autoimmune diseases. Regulation by clusterin/vitronectin prevents uncontrolled damage.
- Other names
- Terminal Complement ComplexTCCC5b-9
02
Mechanism of action
Pore formation in target cell membranes, leading to cell lysis
03
Biological functions
CytolysisImmune defensePore formationCell deathInflammationComplement activation
04
Disease associations
Autoimmune diseasesLupus nephritisKidney pathologiesInflammationTissue injury
05
Safety considerations
Uncontrolled complement activation leading to tissue damageOff-target effects on host cells
06
Biomarkers
sC5b-9 (soluble MAC)
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