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Target intelligence / Profile preview
Integrin alpha-M beta2 receptor (Mac-1)
- Target
- Mac-1
- Molecular classification
- Receptor, Integrin
01
Overview
The integrin alpha-M beta2 receptor (Mac-1, CR3, CD11b/CD18) is a heterodimeric integral membrane protein expressed on leukocytes involved in innate immunity. It mediates inflammation, leukocyte adhesion/migration, phagocytosis, and immune synapse formation. It recognizes a wide array of ligands including iC3b, fibrinogen, Factor X, and ICAM-1. Genetic variants in ITGAM are associated with increased risk for systemic lupus erythematosus.
- Other names
- Macrophage-1 antigenComplement receptor 3CD11b/CD18ITGAM/ITGB2CR3ACluster of differentiation molecule 11B (CD11B)
02
Mechanism of action
N/A
03
Biological functions
Leukocyte adhesionLeukocyte migrationPhagocytosisCell-mediated cytotoxicityChemotaxisCellular activationImmune synapse formationTLR signaling regulation
04
Disease associations
InflammationAutoimmunitySystemic lupus erythematosus
05
Biomarkers
CD11B (macrophage/microglia marker)
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