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Target intelligence / Profile preview
Complement receptor type 2 (CR2)
- Target
- CR2
- Molecular classification
- Membrane glycoprotein, Receptor
01
Overview
Complement receptor type 2 (CR2), also known as CD21, is a membrane glycoprotein that plays a pivotal role in the immune system by linking innate and adaptive immunity. It is expressed primarily on mature B cells and follicular dendritic cells, and functions as a receptor for complement fragments (iC3b, C3dg, C3d) and the Epstein-Barr virus (EBV). CR2 enhances B cell activation and antibody responses, and serves as an entry point for EBV into B lymphocytes. Variations in CR2 expression are associated with autoimmune diseases like SLE.
- Other names
- Complement C3d receptorEpstein–Barr virus receptorCD21C3DRCRCVID7SLEB9
02
Mechanism of action
N/A
03
Biological functions
Immune activationB cell co-receptor complex formationPathogen entry receptorModulation of B cell signaling
04
Disease associations
Systemic lupus erythematosus (SLE)Autoimmune diseasesEpstein-Barr virus (EBV) infectionIschemia-reperfusion injury
05
Safety considerations
Potential for immune dysregulationExacerbation of autoimmune conditionsIncreased risk of EBV infection
06
Biomarkers
Surface expression levels in SLE patients
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