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Target intelligence / Profile preview
Complement System Proteins (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Protease, Regulatory protein, Opsonin, Anaphylatoxin
01
Overview
The complement system is a crucial component of innate immunity, consisting of over 40 proteins. Replacement therapy aims to restore deficient proteins using recombinant technology or plasma-derived products, particularly for rare primary immunodeficiencies or acquired deficiencies.
- Other names
- Complement proteinsComplement factors
02
Mechanism of action
Supplementation with functional complement proteins
03
Biological functions
Immune responseOpsonizationInflammationCell lysisPathogen clearanceRegulation of immune system
04
Disease associations
InfectionAutoimmune diseaseHereditary angioedemaImmunodeficiency
05
Safety considerations
Risk of infection (plasma-derived products)Immunogenicity (recombinant proteins)Thromboembolic events
06
Interacting drugs
Recombinant C1 inhibitor
1 more in the full profile.
07
Biomarkers
Complement protein levels (e.g., C1 inhibitor, C2, Factor H, Factor I, Properdin)
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