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Target intelligence / Profile preview
Complex II of the Respiratory Chain (SDH)
- Target
- SDH
- Molecular classification
- Enzyme, Oxidoreductase, Mitochondrial protein, Respiratory chain component
01
Overview
Complex II is a key enzyme complex in mitochondria, serving as a crucial link between the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). It catalyzes the oxidation of succinate to fumarate in the TCA cycle, transferring electrons from succinate to FAD, then through iron-sulfur clusters, and finally to ubiquinone, reducing it to ubiquinol. Unlike other respiratory complexes, Complex II does not pump protons directly. It has additional roles in ROS generation, apoptosis, and cellular signaling. Mutations or deficiencies in complex II subunits can cause severe metabolic diseases, including cancers and neurodegenerative disorders.
- Other names
- Succinate dehydrogenaseSuccinate-coenzyme Q reductaseSQR
02
Mechanism of action
N/A
03
Biological functions
Electron transportATP synthesisTCA cycleROS generationApoptosis sensing
04
Disease associations
CancerMitochondrial diseasesNeurodegenerative disorders
05
Safety considerations
ROS generationPotential for off-target effects on other metabolic pathwaysDrug-induced mitochondrial toxicity
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