Component of oligomeric Golgi complex subunit 2 (COG2)

Component of oligomeric Golgi complex subunit 2 (COG2) is a protein-coding gene that encodes a subunit of the conserved oligomeric Golgi (COG) complex, which is essential for maintaining the normal structure and activity of the Golgi apparatus. The COG complex, including COG2, facilitates retrograde vesicular trafficking within the Golgi and is required for proper glycoprotein modification and enzyme localization. Mutations in COG2 can cause congenital disorders of glycosylation, leading to defects in protein glycosylation and associated clinical syndromes. COG2 operates by mediating the initial physical contact between transport vesicles and their membrane targets, akin to other Golgi tethering complexes. There are no approved or known drugs targeting COG2, and it is not considered a classical therapeutic target, receptor, enzyme, or transporter.

Other names

Conserved oligomeric Golgi complex subunit 2LDLCCDG2QCOG complex subunit 2Low density lipoprotein receptor defect C-complementing proteinbrefeldin A-sensitive peripheral Golgi proteinconserved oligomeric Golgi complex protein 2low density lipoprotein receptor defect C-complementing protein