Composite endogenous growth factor network (CEGFN)

The composite endogenous growth factor network is a conceptual framework representing the complex, interconnected signaling pathways involving various growth factors such as VEGF, FGF, PDGF, and TGF-beta. These factors work in concert to regulate fundamental cellular processes including proliferation, differentiation, and survival. In a physiological context, this network is essential for tissue repair, embryonic development, and maintaining homeostasis. However, dysregulation of this network is a hallmark of many diseases, particularly cancer, where overactive signaling drives tumor growth and metastasis. Because it describes a broad biological system rather than a single molecular entity, it is not considered a discrete therapeutic target, although individual components within the network are frequently targeted by specific inhibitors or monoclonal antibodies.

Other names

Endogenous growth factor signaling networkGrowth factor signaling pathwaysGrowth factor interactome

Not applicable as this is a conceptual network of multiple signaling molecules rather than a single drug target.