Composite Man9 high-mannose glycan and phosphatidylserine (Man9-PS)

The composite target consisting of Man9 high-mannose glycans and phosphatidylserine (PS) represents a unique molecular signature often found on the surface of enveloped viruses, such as HIV-1, and within the tumor microenvironment. Man9GlcNAc2 is a specific oligosaccharide structure that is densely packed on viral envelope proteins like gp120, while phosphatidylserine is a phospholipid typically sequestered in the inner leaflet of healthy cell membranes but externalized during viral budding or cell stress. Research into this composite target focuses on creating highly specific therapeutic agents, such as multivalent antibodies or bispecific molecules, that can distinguish diseased surfaces from healthy ones by requiring the presence of both markers. By targeting this dual epitope, drugs can neutralize viral particles or direct immune cells to destroy malignant tissues while minimizing impact on normal cells that may express only one of these components at lower densities.

Other names

Man9GlcNAc2 and Phosphatidylserine composite epitopeHigh-mannose glycan and PS complexMan9-PS dual target

Dual-binding or proximity-based recognition where a therapeutic agent (such as a bispecific antibody or a multivalent lectin-fusion) simultaneously or preferentially binds to high-mannose glycans (Man9) and exposed phosphatidylserine on the surface of viruses or tumor cells to trigger neutralization or immune-mediated clearance.