Concentrative nucleoside transporter 3 (hCNT3)

Concentrative nucleoside transporter 3 (hCNT3, encoded by *SLC28A3*) is a plasma membrane protein of the solute carrier family, functioning primarily as a sodium-dependent nucleoside transporter capable of importing both physiological nucleosides and a broad range of nucleoside analog therapeutic agents—including anti-cancer and antiviral drugs—into cells[1][2][3][5][7]. hCNT3 is structurally characterized by a homo-trimeric assembly and is broadly expressed in human tissues, particularly in the kidney and epithelia[1][3][4]. Its broad substrate selectivity and pivotal transport role render it a key determinant of tissue disposition and pharmacological efficacy of nucleoside analog drugs. Genetic variants in *SLC28A3* can modulate function and expression, impacting drug response and toxicity[7].

Other names

SLC28A3CNT3solute carrier family 28 member 3

Facilitates sodium-dependent cellular uptake of nucleosides and nucleoside analog drugs, enabling their cytotoxic or antiviral activity by permitting intracellular accumulation[2][3][7].