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Target intelligence / Profile preview
Condensin complex subunit 3 (NCAPG)
- Target
- NCAPG
- Molecular classification
- Chromosome structural protein, Condensin complex subunit, Structural maintenance of chromosomes (SMC) complex protein
01
Overview
Condensin complex subunit 3 (NCAPG) is a regulatory subunit of the condensin I complex, which is essential for chromosome condensation and stable chromosome segregation during mitosis and meiosis[3][9]. This protein cooperates with NCAPH and NCAPD2 to form condensin I, a complex that converts interphase chromatin into tightly packaged mitotic chromosomes, thus maintaining genome stability during cell division[1][4][6][7]. NCAPG plays a critical role in chromosomal organization and is indispensable for proper cell cycle progression. Overexpression of NCAPG is associated with several cancers, where it promotes proliferation, migration, and drug resistance; its expression correlates with tumor aggressiveness and worse prognosis, making it a potential therapeutic target and prognostic biomarker in oncology[2][4][5].
- Other names
- non-SMC condensin I complex subunit Gcondensin subunit CAP-GCAP-G
02
Mechanism of action
Disruption of NCAPG impairs chromosome condensation and segregation, inhibits tumor cell proliferation and migration, and induces cell cycle arrest; targeting NCAPG may reduce tumor cell growth
03
Biological functions
Chromosome condensationChromosome segregationCell cycle regulationMaintenance of chromosomal stabilityCell proliferation
04
Disease associations
Cancer (e.g., hepatocellular carcinoma and other tumors)Tumor recurrenceDrug resistance
05
Safety considerations
Possible effects on normal cell divisionpotential genomic instability if targeted broadlyrisk of impaired tissue regeneration
06
Biomarkers
Overexpression of NCAPG as a biomarker for tumor progression, recurrence, and prognosis in several cancers
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