Target intelligence / Profile preview

Conditionally Replicative Oncolytic Adenovirus CRAd-S-pk7 (CRAd-S-pk7)

Target: CRAd-S-pk7
Molecular classification: Oncolytic Virus, Adenovirus, Conditionally Replicative Adenovirus

Overview

CRAd-S-pk7 is a conditionally replicative oncolytic adenovirus designed for targeted tumor cell lysis. Its replication is controlled by the survivin promoter, restricting viral gene expression to cells with high survivin activity. The adenoviral fiber protein is modified with a polylysine motif (pk7) to enhance cell entry. It is often delivered via neural stem cells (NSCs) to protect it from neutralizing antibodies and improve targeting.

Other names: CRAd-S-pk7Oncolytic Adenovirus CRAd-S-pk7

Mechanism of action

Selective replication in survivin-expressing tumor cells leading to oncolytic lysis and induction of anti-tumor immunity.

Biological functions

Tumor cell lysisAnti-tumor immunity inductionViral replicationInfection of cancer cells

Disease associations

Glioblastoma multiformeMetastatic ovarian cancerEndometriosis (potential)

Safety considerations

Off-target toxicity (reduced by tumor selectivity)Potential for immune response against the virusRisk of viral shedding

Biomarkers

Survivin expression level (for patient selection)Tumor antigen exposure (for efficacy monitoring)

Beyond the preview

Go deeper on Conditionally Replicative Oncolytic Adenovirus CRAd-S-pk7 (CRAd-S-pk7).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Conditionally Replicative Oncolytic Adenovirus CRAd-S-pk7 (CRAd-S-pk7).

Explore the full profile