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Target intelligence / Profile preview
Connective Tissue Growth Factor (CTGF)
- Target
- CTGF
- Molecular classification
- Matricellular protein, Extracellular matrix-associated heparin-binding protein
01
Overview
Connective tissue growth factor (CTGF), also known as CCN2, is a matricellular protein that plays critical roles in cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair. It is especially important in fibrotic diseases and several forms of cancer due to its regulatory effects on extracellular matrix (ECM) production and remodeling. CTGF interacts with multiple receptors, including integrins and LRP6, and modulates signaling pathways such as TGF-beta and Wnt. It is being explored as a therapeutic target for fibroproliferative diseases.
- Other names
- CCN2
02
Mechanism of action
Therapeutics targeting CTGF are under investigation for treating fibrotic diseases due to its pivotal role downstream from TGF-beta signaling cascades that drive pathological ECM accumulation.
03
Biological functions
Cell proliferationCell migrationCell adhesionAngiogenesisSkeletal developmentWound healingECM modulation
04
Disease associations
FibrosisCancerAtherosclerosis
05
Safety considerations
Potential for off-target effects due to broad expression and multiple binding partnersComplex role in different disease contexts (e.g., pro- or anti-tumorigenic effects in certain cancers)
06
Biomarkers
CTGF expression levels
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