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Target intelligence / Profile preview
Connective Tissue Growth Factor Messenger RNA (CTGF mRNA)
- Target
- CTGF mRNA
- Molecular classification
- mRNA, Matricellular protein mRNA
01
Overview
Connective tissue growth factor (CTGF), also known as CCN2, is a matricellular protein encoded by the CTGF gene. The messenger RNA (mRNA) for CTGF is transcribed from this gene and serves as the template for translation into the CTGF protein. CTGF mRNA plays a central role in cell proliferation, migration, adhesion, survival, differentiation, and synthesis of extracellular matrix (ECM) proteins. It is critically involved in wound healing and fibrotic diseases and contributes to angiogenesis, skeletal development, and tissue repair processes. Elevated expression of CTGF has been observed in several cancers.
- Other names
- CCN2 mRNA
02
Biological functions
Template for protein translationRegulation of cell proliferationRegulation of cell migrationRegulation of cell adhesionRegulation of cell survivalRegulation of cell differentiationRegulation of extracellular matrix (ECM) synthesis
03
Disease associations
Fibrotic diseasesCancerWound healing
04
Safety considerations
Overexpression leading to fibrosisOverexpression leading to tumor progression
05
Biomarkers
CTGF mRNA expression levels as a biomarker for disease progressionCTGF mRNA expression levels as a biomarker for therapeutic response
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