Gosset Molecular Classification
mRNA
Other Names
CCN2 mRNA
Disease Roles
Connective Tissue Growth Factor mRNA Overview
Messenger RNA (mRNA) for connective tissue growth factor (CTGF), also known as CCN2, is the transcript produced from the CTGF gene. This mRNA encodes a secreted matricellular protein that plays a key role in cell proliferation, differentiation, migration, adhesion, survival, and extracellular matrix production. The CTGF gene is an immediate early response gene and belongs to the CCN family of proteins. Elevated levels of CTGF mRNA are associated with pathological conditions involving excessive connective tissue deposition.
Mechanism of Action
Biological Functions
Regulates expression of CTGF protein
Mediates CTGF's role in cell proliferation
Mediates CTGF's role in cell differentiation
Mediates CTGF's role in cell migration
Mediates CTGF's role in cell adhesion
Mediates CTGF's role in cell survival
Mediates CTGF's role in extracellular matrix production
Disease Associations
Fibrosis
Wound healing
Cancer (e.g., Glioma)
Safety Considerations
- Targeting CTGF mRNA translation or regulation could have unintended effects on wound healing and tissue regeneration
Associated Biomarkers
| Biomarker |
|---|
| High levels correlate with poor prognosis in glioma |