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Target intelligence / Profile preview
Connective Tissue Growth Factor mRNA (CTGF mRNA)
- Target
- CTGF mRNA
- Molecular classification
- mRNA
01
Overview
Messenger RNA (mRNA) for connective tissue growth factor (CTGF), also known as CCN2, is the transcript produced from the CTGF gene. This mRNA encodes a secreted matricellular protein that plays a key role in cell proliferation, differentiation, migration, adhesion, survival, and extracellular matrix production. The CTGF gene is an immediate early response gene and belongs to the CCN family of proteins. Elevated levels of CTGF mRNA are associated with pathological conditions involving excessive connective tissue deposition.
- Other names
- CCN2 mRNA
02
Biological functions
Regulates expression of CTGF proteinMediates CTGF's role in cell proliferationMediates CTGF's role in cell differentiationMediates CTGF's role in cell migrationMediates CTGF's role in cell adhesionMediates CTGF's role in cell survivalMediates CTGF's role in extracellular matrix production
03
Disease associations
FibrosisWound healingCancer (e.g., Glioma)
04
Safety considerations
Targeting CTGF mRNA translation or regulation could have unintended effects on wound healing and tissue regeneration
05
Biomarkers
High levels correlate with poor prognosis in glioma
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