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Connective Tissue Growth Factor Receptor (None)
- Target
- None
- Molecular classification
- Integrin, Low-density lipoprotein receptor-related protein, Heparan sulfate proteoglycan, Receptor Tyrosine Kinase
01
Overview
Connective Tissue Growth Factor (CTGF/CCN2) is a matricellular protein that does not have a single, dedicated receptor. It interacts with several cell surface proteins, including integrins (α5β1, αvβ3), low-density lipoprotein receptor-related proteins (LRPs) like LRP6, heparan sulfate proteoglycans (HSPGs), and TrkA. These interactions regulate cell adhesion, migration, proliferation, angiogenesis, wound healing, skeletal development, and fibrosis. Therapeutic strategies target CTGF itself or its interactions with integrins or LRP6 to modulate pathological processes.
- Other names
- CTGF ReceptorCCN2 Receptor
02
Mechanism of action
Monoclonal antibodies against CTGF or agents disrupting ligand-receptor interactions.
03
Biological functions
Cell proliferationCell differentiationCell migrationExtracellular matrix synthesisAngiogenesisWound healingFibrosis
04
Disease associations
Organ fibrosis (liver, lung, kidney)TumorigenesisMetastasisFibroproliferative diseasesScarring disorders
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