Connector enhancer of kinase suppressor of Ras 2 (CNKSR2)

Connector enhancer of kinase suppressor of Ras 2 (CNKSR2, also known as CNK2 or MAGUIN) is a multidomain scaffold protein encoded by the *CNKSR2* gene on the X chromosome[1][2][3][5]. It contains domains such as SAM, PDZ, PH, and CRIC, enabling it to interact with multiple proteins in signaling complexes. CNKSR2 regulates the mitogen-activated protein kinase (MAPK) pathway downstream of Ras and coordinates the assembly of synaptic proteins at postsynaptic sites[1][2][3][5]. It plays a critical role in neuronal development, promoting dendrite and dendritic spine formation, and is implicated in various neurodevelopmental disorders including intellectual disability, epilepsy, and autism spectrum conditions[2][3][5]. Defects or mutations in CNKSR2 result in X-linked intellectual disability with associated neurological symptoms. No direct drugs are listed that target CNKSR2, and it is not primarily considered a therapeutic target but is a significant disease gene in neurodevelopmental genetics[2][3][5].

Other names

CNK2KSR2MAGUINCNK homolog protein 2KIAA0902MRXSHGmembrane-associated guanylate kinase-interacting protein