Target intelligence / Profile preview

Connexin Protein (Cx)

Target: Cx
Molecular classification: Transmembrane protein, Gap junction protein

Overview

Connexins are a family of transmembrane proteins that form gap junctions, enabling direct intercellular communication by allowing the passage of ions and small signaling molecules between adjacent cells. They are essential for various physiological processes, including electrical signal propagation and metabolic cooperation. Mutations or dysregulation in connexin genes can lead to various diseases.

Other names: Gap junction proteinConnexonGJA1GJB1GJB2Cx26Cx32Cx43

Mechanism of action

Modulation of gap junction communication

Biological functions

Intercellular communicationElectrical signal propagationMetabolic cooperationIon transportSignal transduction

Disease associations

Hearing lossCharcot-Marie-Tooth diseaseCardiac arrhythmias

Safety considerations

Dysregulation can lead to various diseasesMutations can impair trafficking or channel formation/functionality

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