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Connexin43 Gap Junction Protein (Cx43)
- Target
- Cx43
- Molecular classification
- Connexin, Gap junction protein
01
Overview
Connexin43 (Cx43), encoded by the GJA1 gene, is a member of the connexin family of proteins that form gap junctions, facilitating direct communication between adjacent cells. It is critically involved in various tissues, including heart, vasculature, nervous system, and skin, playing roles in metabolic cooperation, electrical coupling, and cell signaling. Dysregulation of Cx43 is linked to diseases such as ODDD, cardiac arrhythmias, cancer, and vascular diseases.
- Other names
- Gap junction alpha-1 proteinGJA1 protein
02
Mechanism of action
Modulation of gap junction communication, hemichannel activity, or gap-junction-independent signaling.
03
Biological functions
Intercellular communicationMetabolic cooperationElectrical couplingSynchronization of cellular activityPropagation of calcium wavesRegulation of cell growth/death signalsMembrane traffickingIntracellular signalingATP release
04
Disease associations
Oculodentodigital dysplasia (ODDD)Cardiac arrhythmiasCongenital heart malformationsCancerVascular diseasesDiabetes-related vascular complications
05
Safety considerations
ArrhythmiasPotential effects on cell proliferation and metastasis
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