Conserved oligomeric Golgi complex subunit 1 (COG1)

Conserved oligomeric Golgi complex subunit 1 (**COG1**) is one of eight subunits forming the conserved oligomeric Golgi (COG) complex, a peripheral protein assembly crucial for maintaining normal Golgi morphology, trafficking, and glycosylation function in eukaryotic cells[1][2][4][5][6][7]. COG1 is a member of lobe A of the complex and acts both as a structural scaffold and as a key mediator of retrograde vesicle tethering—enabling proper recycling and localization of Golgi-resident glycosylation enzymes and other proteins[1][2][3][5]. Mutations disrupting COG1 function destabilize the complex and impair Golgi enzyme targeting, resulting in combined defects of N- and O-linked glycosylation and leading to congenital disorders of glycosylation (CDG)[2][3][5][6]. Though critical for Golgi and cellular homeostasis, COG1 is not an enzyme, receptor, or transporter, and has no direct therapeutic ligands; disease is associated solely with loss-of-function and structural instability[1][2][3][4][5][6][7].

Other names

Component of oligomeric Golgi complex 1COG1KIAA1381LDLBCOG complex subunit 1CDG2GLow density lipoprotein receptor defect B complementing

Not applicable (no drugs directly targeting COG1)