Conserved oligomeric Golgi complex subunit 3 (COG3)

Conserved oligomeric Golgi complex subunit 3 (COG3) is an essential subunit of the conserved oligomeric Golgi (COG) complex, a multiprotein complex comprising eight subunits that is required for normal Golgi morphology and function. COG3 participates in the tethering of retrograde intra-Golgi vesicles, a key step prior to their fusion with Golgi cisternae, and is crucial for maintaining Golgi organization, dynamics, and appropriate protein glycosylation. Disruption of COG3 or the larger COG complex leads to Golgi fragmentation and multiple defects in protein glycosylation, underlying congenital disorders such as congenital disorder of glycosylation type IIbB. COG3 interacts functionally with other COG complex subunits to regulate vesicular trafficking between the ER and Golgi, and is not considered a classical drug target such as a receptor, enzyme, or transporter, but rather is a key component of the vesicle tethering apparatus within the Golgi apparatus[1][2][3][4].

Other names

SEC34COG complex subunit 3p94vesicle-docking protein SEC34 homologCDG2BBtethering factor SEC34