Conserved oligomeric Golgi complex subunit 4 (COG4)

Conserved oligomeric Golgi complex subunit 4 (COG4) is a protein subunit of the conserved oligomeric Golgi (COG) complex, a crucial multiprotein machinery required for maintaining structure and intracellular function of the Golgi apparatus. The COG complex is essential for correct protein glycosylation and vesicle tethering, mediating the retrograde transport of proteins and lipids from the Golgi apparatus back to the endoplasmic reticulum. COG4 provides important structural and tethering functions within the COG complex, ensuring proper modification and sorting of glycoproteins and other cargo critical to normal cellular operations. Mutations in COG4 disrupt glycosylation pathways, causing congenital disorders such as congenital disorder of glycosylation (COG4-CDG) and Saul-Wilson syndrome, which are characterized by developmental delays, intellectual disability, skeletal and growth abnormalities, and other severe systemic manifestations. There are no known small molecule drugs or therapeutic biologics clinically targeting COG4.

Other names

COG4CDG2JCOD1Component of oligomeric Golgi complex 4SWILSDKFZP586E1519COG complex subunit 4