Conserved oligomeric Golgi complex subunit 5 (COG5)

Conserved oligomeric Golgi complex subunit 5 (COG5) is a component of the COG complex, an eight-protein assembly crucial for maintaining Golgi apparatus structure and mediating protein and lipid glycosylation. COG5 is centrally involved in the retrograde transport of vesicles within the Golgi apparatus, particularly recycling glycosylation enzymes and ensuring proper protein modification and sorting. It forms part of the lobe B subcomplex (with COG6, COG7, COG8), adopting a CATCHR (Complexes Associated with Tethering Containing Helical Rods) fold that mediates protein-protein interactions vital for vesicle tethering. Mutations in COG5 cause congenital disorders of glycosylation by disrupting Golgi trafficking and glycan processing, leading to developmental, neurological, and multisystem disease[1][2][3][4]. There are currently no known drugs targeting COG5; the gene and its protein product function as an essential vesicle trafficking scaffold rather than a conventional therapeutic target.

Other names

Component of oligomeric Golgi complex 5GOLTC1GTC90COG complex subunit 5GTC-9013S Golgi transport complex 90 kDa subunitGolgi transport complex 1CDG2IConserved oligomeric Golgi complex protein 5