Conserved oligomeric Golgi complex subunit 7 (COG7)

Conserved oligomeric Golgi complex subunit 7 (COG7) is a protein encoded by the COG7 gene located on chromosome 16 (16q12.2) in humans[1][2][4]. COG7 is one of eight subunits of the conserved oligomeric Golgi (COG) complex, a multi-protein complex critical for maintaining the structure and function of the Golgi apparatus[1][3][4]. This complex mediates the tethering and fusion of vesicles carrying glycosylation enzymes and other Golgi-resident proteins, ensuring proper trafficking, localization, and modification of glycoproteins via N- and O-linked glycosylation pathways[1][2][3][4]. COG7, in association with subunits COG4, COG5, and COG6, forms part of a structural and functional core essential for these trafficking processes[3]. Mutations in COG7 or other subunits disrupt glycoprotein processing, leading to congenital disorders of glycosylation (CDG), most notably COG7-CDG, a rare, inherited multisystem disorder presenting with developmental delay, neurological dysfunction, organ involvement, and abnormal glycan structures on serum proteins[1][2]. There are currently no approved drugs targeting COG7, and it is not classified as a typical therapeutic target such as a receptor, enzyme, or transporter[1][2][3][4].

Other names

Component of oligomeric Golgi complex 7COG complex subunit 7CDG2EUNQ3082/PRO10013