Consortin (CNST)

Consortin (CNST) is an integral membrane protein that acts as a cargo receptor in the trans-Golgi network, responsible for targeting connexins (the building blocks of gap junctions) to the plasma membrane and facilitating their recycling from the cell surface. It binds connexins and interacts with adaptor machinery to enable proper trafficking of these transmembrane proteins. Consortin is implicated in disorders involving connexin dysfunction, such as certain types of thyroid dyshormonogenesis and familial hypertrophic cardiomyopathy[1][3][5][7][9]. There is no evidence that CNST itself acts as a therapeutic target, receptor, enzyme, transporter, or transcription factor.

Other names

ConsortinCNSTConnexin sorting proteinC1orf71PPP1R64FLJ32001Protein phosphatase 1 regulatory subunit 64