Contact lens deposits

Contact lens deposits refer to the accumulation of tear film components, including proteins (such as lysozyme, lactoferrin, and albumin), lipids, and mucins, onto the surface and within the matrix of a contact lens during wear (Subbaraman et al., 2006). These biomaterials can undergo denaturation or oxidation, leading to reduced visual acuity, physical discomfort, and inflammatory responses like giant papillary conjunctivitis (Jones et al., 2003). While some proteins like lysozyme maintain antimicrobial activity when adsorbed in their native state, their denaturation can trigger immune reactions and facilitate bacterial adhesion, increasing the risk of microbial keratitis (Willcox, 2013). Management typically involves the use of surfactants and enzymatic cleaners in contact lens care solutions to remove these materials and maintain lens biocompatibility (Stapleton et al., 2008). These cleaning agents, such as poloxamers and proteolytic enzymes, target the deposits to prevent biofouling and ensure the safety of the ocular surface. Although not a single therapeutic target, the study of these deposits is crucial for developing materials with improved resistance to fouling and more effective lens care systems.

Other names

Tear film depositsContact lens biofoulingProtein depositsLipid depositsLens surface contaminants

Removal of deposits via enzymatic hydrolysis of proteins, solubilization of lipids by surfactants, and oxidative disinfection.