Contactin-2 (CNTN2)

Contactin-2 (CNTN2) is a 135 kDa neuronal cell adhesion molecule anchored to the cell membrane via a GPI moiety, with six immunoglobulin-like domains and four fibronectin III-like domains[2]. It is transiently expressed on axons during development and persists in certain neuronal populations postnatally, being critically involved in axonal growth, guidance, fasciculation, and myelination[2][4]. CNTN2 participates in axo-glial and synaptic junctions through homo- and heterophilic binding (notably with CNTNAP2/Caspr2), essential for the clustering of potassium channels at juxtaparanodes and synaptic organization[1][2][4]. Dysfunction, aberrant expression, or autoimmune targeting of CNTN2 is implicated in a range of CNS diseases, including multiple sclerosis, neurodevelopmental and neurodegenerative disorders, and CNS tumors[2]. Clinical approaches may leverage its role as a biomarker, but direct targeting is currently experimental.

Other names

TAG-1transient axonal glycoprotein 1axonin-1TAX-1AXTFAME5EPEO5axonal glycoprotein TAG-1contactin 2 (transiently expressed)contactin-2axonin-1 cell adhesion molecule

not applicable